My niece is 18 years old, she has mdr tb with meningitis. She has completed almost 8 month treatment with below medicines, she is on amikacin 600 mg * 5 days a week injection for almost 8 months, along with dexa 0.5 mg (steroid). Dexa tapered from 12 mg to 1 mg gradually, but she has developed avn so dexa 1 mg suddenly stopped. After 3 days of dexa 1 mg stopped, she stared to get fever & vomiting & neck pain. Is it due to dexa stopped? Her doctor suspects this fever is because of one of the mdr tb drug so she has suggest to stop all mdr tb medicines. Also yesterday when were checking her fever, the bip of thermometer she is not able to hear, even we brought the thermometer close to her ear even then also was not able to hear but what we speak she can here clearly. Is it because of amikacin? Should we stopped amikacin as only 10 days left to complete 8 months amikacin course. What would be the next plan about amikacin if the problem is like this. Request you to please suggest at the earliest. Amikacin 600 mg * 5 days a week ethionamide 250 mg 1-1 linezolid 300 mg clofazimine 100 mg cycloserine 250 mg 1-1 moxifloxacin 400 mg dexa 4-4-4 18 days then taper off.