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Doctor in 2017 my daughter was diagnosed by nephritic syndrome, case of neph syn since the age of 3, (2017), has had two relapses, but steroid responsive, patient was off steroids. Now with vomiting, pain in abdomen, create 2,1, reduced urine output to 0.8-1.2 ml/hr, renal failure not improved, urine routine 4+ alb, pus cells 3-4, rbc 30-35, urine showed yeast cells but culture neg, eosinophil in urine, 73 mg blood urea. Kidney biosphy was also performed which said, all the glomeruli are minimally involved and the immunofluorescence is negative. In the presence of nephrotic range proteinuria, the above features favour a minimal change disease with prominent tubular injury. The tubules show large zones of injury. Few reveal prominent isometric vacuoles. Some show granular appearance of the cytoplasm and occasional contain hyaline material. She was discharged on 27th as the condition was less severe, with 23 mg blood urea, ++++ alb in protein. And steroid started, prednisolone, but from yesterday the swelling increased, urine output decreased. Is it is normal for few days after starting steroids or should I consult the doctor immediately.


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