My father in law has been diagnosed with stage 4 lung cancer in june 2017. He went through 6 chemotherapy cycles. Then due to exon 19 mutation he was on erlotinib for 2 years. Last year erlotinib stopped working so doctors prescribed him osimeritinib and he is on osimeritinib from last 1 year but now he started feeling very tired, his breathing issue increased, cough is increased, and his ribs are paining. He was on oxygen support for 2 days. Is it something serious.

Dr. Govind Preet SinghOncologist10yrs exp

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Good evening. The symptomscould be due to multiple reasons here (ribs metatasis, pleural effusion, disease progression). There is a high probability of osimeritinib induced pneumonitis, should get an hr-ct chest done, to rule it out and to ascertain local disease status in lungs. Take care.  

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Hi lybrate-user. Lung cancer does not carry a good prognosis. Your father in lawhas stage 4 disease which has been treated with chemotherapy and targeted therapy. If your father in law has developed respiratory problems even after osimertinib, it means that the disease is in progression. He should undergo imaging with ct scan of chest to assess the disease extent.  

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