Can I switch clomid to letrozole if clomid fail to get pregnant after 4 round but I am ovulated my progesterone level is 14 in day 21 of cycle but no pregnancy please tell me if 4 cycle of clomid fail to get pregnant so I never become pregnant and how many rounds of Clomid I take in life I am suffering from PCOS.

Dr. Nikita BanerjeeGynaecologist12yrs exp

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Dear lybrate-user, not more than 6 cycles of clomid are usually prescribed and yes you may switch to letrozole but don't self medicate. You must do it under observation and with proper consultation as there are associated risks such is ovarian hyper stimulation and side effects on the lining of uterus. I specialise in infertility and pcos management and I would suggest that other causes of infertility should be ruled out as pcos may be a contributing factor but not the only factor.  

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Dr. Balachandran PrabhakaranGynaecologist47yrs exp

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Better go for letrazole 2.5 mg from the second day of the period. The success rate is 12%.Monitor follicular growth trans vaginally. 

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