I am a 62-year-old male. I am suffering from Polycythemia Rubra Vera (due to JAK 2 mutation) for last 8 years. First 3 years I was put on treatment with low level of aspirin, amlodipine and periodic venesection. Last 5 years I am on Hydroxyurea along with the above mentioned drugs. The dose of hydroxyurea is adjusted periodically based on FBC. My questions are: 1. What are the adverse effects of long term treatment with Hydroxyurea? 2. I get occasional muscle cramp. How do I get relief from it? I would like to know 1. What is the adverse drug effect of long term intake of Hydroxyurea. 2. I suffer from painful muscle cramp occasionally. What I should do to get relief from it?
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Side effects re hair loss; skin peeling or discoloration, mild rash; upset stomach, constipation, diarrhea, vomiting; headache, dizziness, drowsiness; or.Less serious side effects may include: hair loss; skin peeling or discoloration, mild rash; upset stomach, constipation, diarrhea, vomiting; headache, dizziness, drowsiness; or weight gain. Muscle cramps may benefit from Calcium tablet
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Every drug has side effects. Use is based on benefits vis -a -vis side effects. Hydroxy urea is well used in blood disorders, specially of neoplastic variety. Important side effects are -bone marrow depression, gastrointestinal disturbances, impairment of renal function, pulmonary oedema, mild dermatological reactions. Loss of hair and neurological manifestations. Most of muscle cramps, if not very severe can be relieved by stretching the muscle, movements or maintenance of electrolyte balance. Topical muscle relaxants can also be lightly used without massaging,
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