My mother aged 53 had been diagnosed with left frontal glioma (anaplastic astrocytoma grade 3 in aug 2019). Patient (female) age ? 53 years (anaplastic astrocytoma grade iii) aug 2019 - symptom ? seizure & loss of consciousness diagnosis with left frontal glioma (anaplastic astrocytoma grade iii) aug 2019 ? treatment ? left frontal craniotomy & gte of glioma followed by rt & chm oct 2019- nov 2019 radiotherapy by imrt with dosage ? 60gy/30# @200cgy/#,5#/week (completed with) concurrent temozolomide (nublast 120 mg) was given & was stopped after 25 sessions of rt due to thrombocytopenia nov 2019 ? oct 2022 ? no complains & normal medication of encorate chrono 500 mg once a day was given. Half yearly mri was done. 6 nov 2022 ? episode of irrelevant talks for 90 mins & behavioral change was seen & was hospitalized for observation & discharged on next day after contrast mri current condition of patient ? absolutely normal current mri reporting ? local recurrence & infiltration into adjacent cerebral parenchyma I am looking for right treatment plan for the same weather chemo has to be taken or re-surgery would be better option and what would be the technical advancements that would be better to have for safe brain surgery. For better review I am sharing the link having all the medical records along with dicom files.