Dear Dr. My mother taking Lasix (half a tablet in the morning). After started to taking Lasix serum creatinine and urea become high. What is the reason for this?

Question

Lasix or frusemide is a loop diuretic and it acts in the ascending limb of loop of henle (its an anatomical part of nephrons which are functional part of the kidney) and it inhibits the sodium-potassium-chloride channel functioning and we loose sodium, potassium and chloride from our body and sometimes it can damage the functionality of the cells of the loop of henle leading to decrease in excreting the toxins from our body and hence there is rise in creatine and urea levels.

Jatin Soni · Accepted Answer

Lasix or frusemide is a loop diuretic and it acts in the ascending limb of loop of henle (its an anatomical part of nephrons which are functional part of the kidney) and it inhibits the sodium-potassium-chloride channel functioning and we loose sodium, potassium and chloride from our body and sometimes it can damage the functionality of the cells of the loop of henle leading to decrease in excreting the toxins from our body and hence there is rise in creatine and urea levels.