Writing on behalf of my mother. She will be 49 YO this Nov. She has a history of painful periods with heavy flow. She has fibroids on the uterine wall and has been undergoing treatment for several years. She was having Novelon OC for about 2 years. She often took the pills at a stretch for 1.5- 2 months with the doctors permission so the periods were delayed. A few months back her bleeding started inspire of the Novelon pills (taking two pills a day). So she consulted another doc who prescribed Regestrone Sandoz .5 mg. Taking the pills twice a day was showing light spotting so she consulted with the doc and started having 3 pills a day after which the bleeding completely stopped until she stopped taking the pills to get started with periods. The last usg done 2 months back shows that the uterus size and wall thickness have grown. Is this due to overuse of Novelon? Is it possible these irregularities are happening because she is approaching menopause? Her doc said she might need to get a biopsy done. Is this really anything serious? Pl reply asap as are all extremely worried.