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Hello sir, My dad is 64 years old. He suffers from type 2 diabetes and hypertension. He takes olmezest am 40 for HTN. My question is - can he take OLMAX LN 40 as it contains another calcium channel blocker cilnidipine at 10 mg (5 mg cilnidipine is not available with olmesartan. As per my research on pubmed articles are in favor of cilnidipine as cilnidipine is an N-type and L-type CCB that also inhibits sympathomimetic activity in contrast to other DHPs and amlodipine therapy has adverse effects, most commonly pedal edema. So Cilnidipine being an N-type and L-type CCB is associated with lower incidence of pedal edema compared to the L-type channel blocked by amlodipine.
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Clinically seen effect of Cilnidipine is different from Amlodipine in a lot of patients. Although, 10 mg of Cilnidipine is considered equivalent to 5 mg of Amlodipine, a shift from Amlodipine to Cilnidipine may lead to reduced efficacy atleast fir the first 1-2 weeks. You may change the medicines if unacceptable pedal edema is present.
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