My mother in law 56 years, 76 kg weight, height 5 ft3 inch, known diabetic for 10 years, hypothyroidism taking thyroxine 100 mg daily ,taking insulin, undergone angiography and single artery standing 1 year back, taking all required medication and regular follow up, takes an anti anxiety medication called depolv 37 (mixture of imiprime plus 2 more drugs].recently did a nuclear myocardial perfusion study, which came out normal. Yet she constantly complaint of pain in upper left chest area and breathless on getting up stairs and on getting up from toilet. No physical activity as she feels exhausted after few rounds of slow walk. Feels drowsy all dsy and remain lie down on bed day long and gets less sleep in night. Consulted all the relevant doctors, who gave same impression of all normal state and advised her proper diet and physical work out. She has weak mental strength so gets panicked easily. So I request for suggestions to get her back to normal state. Please help ?I'm a dental surgeon by profession, so if the below interpretation help you, please go thru. She is already on ecosprin, atorvastatin,metoprolol, nitrocontin,ranulaz500, thyroxine100 mg,Metformin 500 mg twice daily, brilinta90 mg,insulin (mixed 30 twice daily 20 units morning and 12 units night. Antienxiety drug depolv 37 bed time. Her recent lipid profile is normal, so as the renal, liver profiles only the tsh was 21, so increased the does from thyroxine25 mg to 100 mg. As per her treating cardiologist all vitals regarding heart is fine. He gave a impression of psychosomatic pain. As per his suggestion myocardial perfusion test under stress was done which also came normal. Her Hb1AC was 7 and ppbs was 170 mg/dl. Creatinine is within normal range, so as the calcium, CBC and urine findings. Please suggest.