Echo lipids sugar calcium creatinine urea vitamin d normal except b12 which is still 200. Earlier I was on concor am 5 twice daily still my systolic bp was elevated 140 to 150. From june 8th my doc changed my medication to calaptin sr 120 once a day. My systolic is still elevated. My thyroid profile kept on changing april tsh 7.49 t3 t4 normal. May tsh 6.01 t3 lower side t4 normal. How many days this medicine takes to show it?s effect and how long does effect of this medicine last 12 hrs or 24 hrs. Having most of the tests normal why is it my bp does not stabilise to normal. Feel fatigued and calf muscles week. Kindly advice.