My questions are described as below. 1. If one having chronic psychological stress "while" receiving primary series of anti rabies vaccination which is 5 arv doses on post exposure prophylaxis, will high level of cortisol hormone or this chronic psychological stress during those times prevent our immune system to mount a proper response to the vaccine? 2. I believe reduction of antibodies level overtime is a normal process. Chronic psychological stress will be elevated cortisol hormone, does this high level of cortisol or chronic psychological stress causes formerly protected level 0.5iu of rabies antibodies drop to unproductive level? (hope to understand more about antibodies during this event as I ever administered 5 doses of arv 3 years ago) 2. If one having protective rabies antibodies level 0.50iu or more, our antibodies kill the virus instantly once it's in site before it enters the nerve? How long does it take for our antibodies to kill the virus? Assume the virus already entered the nerve and spinal cord but it hasn't reached the brain will our antibodies still be able to kill it? 3. Will chronic psychological stress or high cortisol level affect or alter hepatitis c antibodies and hiv antibodies "seroconversion" process? (means production of antibodies affected therefore unable to properly seroconvert of antibodies due to severe level of stress or chronic psychological stress) 4. For hiv infection I have seen few discussions from Dr. h. Hunter handsfield (hiv expert) through medhelp forum with his patients that antibodies will clear p24 out of the blood until p24 no longer detectable and excess antibodies will start detectable through serology blood test afterward as part of seroconversion. A. For hiv if one having psychological stress or chronic psychological stress or high cortisol level will production level of antibodies that produce by our immune system stop or delay while in the middle of clearing p24 due to stress? I seen some of this p24 discussion from h. Hunter handsfield m.d (hiv expert) with his patient which I screenshot their conversation in the attachment above (kindly refer to the attachment in the above for more detail) he mentioned "in other words, the p24 cannot become negative until at least several days (typically a couple of weeks) after antibody appears" by h. Hunter handsfield m.d. B. I'm concern about will antibodies stop or delay production during that stressful event due to stress which causes improper seroconversion? (probably similar questions to no. 3 but a little more detail:) 5. If one having chronic psychological stress and high cortisol level, will one seropositive infections such as hiv or hcv (hepatitis c) "seroreversion" to seronegative? (i do understand for hiv positive patient seroreversion for hcv is common, although i'm not hiv positive and read some cases mentioned antibodies for hcv persist for life, some said persist for many years or up to decades. 6. If one having psychological stress such as anxiety which is either chronic or not chronic does it affects seroconversion process of antibodies for treponemal test on infection like syphilis (such as tpha, fta-abs) or non treponemal test on syphilis? (such as vdrl, rpr). 7. If one having severe psychological stress anxiety or chronic psychological stress does it causes syphilis treponemal test or non treponemal test antibodies seroreversion? (despite I seen some expert discussed overtime seroreversion for non treponemal test which test turning to negative overtime is normal and is the only issue for non treponemal that might be due to the nature of the test itself which does not happen to treponemal test).