Hi Sir, My brother had cough & fever from Sept-Nov 2015 he was on Antibiotics, Paracetamol and cough syrup for same time but didn't got any relief finally done Chest CT scan in Nov and found Pleural Effusion, pleural fluid aspirate done on 24th Nov but whole fluid didn't not aspirated because patient get vertigo problem during aspiration so doctor stop aspiration, from 24th Nov TB treatment started. He got mild relief from cough and fever But after 15-20 days he again faced severe cough and mild fever, again CT scan and Chest sonography done and found some pleural fluid. Again, pleural fluid aspiration done and TB treatment continue, from that day he started getting relief day by day. Now is feeling absolutely fine. TB treatment is continue from Nov till today. From April he started feeling Hip shoulder back knee and Feet pain, some blood test done and found Vitamin B12 & Vitamin D is very much deficient. Both vitamin B12 and D injections and capsules Tablets supplement started and got felling better but didn't get any relief in Feet pain. Since last 40 days he having pain, pin needles and burning sensation in both feet.As per doctor prescription all types pain killer reliever like Dynapar SR, Zobid Zerodol SP etc taken but till today didn't got any relief in feet pain, even pain killer didn't work for 1 hour. We took opinion from Orthopedic and Neuro Surgeon and done MRI of Spine and Feet, MRI is normal as per MRI report but Feet pain and burning is still persist Now we consult with Neurologist, he said it look that it's Neuropathy due to TB medicine Isonizad. He said to consult TB physician and stop taking Isonizad and he prescribed Tab Pregabalin, Zen 100, Ultracet and Deep Senz ointment. We again consult with our TB physician, he said TB drug Isonizad can't be withdrawal because if we stop it TB May relapse later. As per doctor TB treatment will continue for more 3 months i. E. Till the end August Feet pain burning pin needles sensation is still persist. So now we are very confused and can't understand what to do. We have following questions 1 Please advise us what to do 2 Is Neuropathy is permanent? 3 Can neuropathy can be cured? 4 Can we stop Isonizad? Thanks & regards.