This is 57 years female from Kolkata. I'm a diabetic (take (GLIMEPIRIDE 2 mg + METFORMIN 500 mg) after breakfast & METFORMIN 500 mg after dinner) & 10 iu insulin overnight ,fasting 80, PP 287 measured today. I want to know can I take glimepiride 2 mg+ metformin 1000 me twice a day to lower the glucose level. For the last 1 year, I'm seeing that my fasting glucose level is under 100, but PP is above 200. More over what is the difference will be in result if a patient take GLIMEPIRIDE 2 mg + METFORMIN 1000 mg instead of GLIMEPIRIDE 1 mg + METFORMIN 1000 mg?

Dr. Prabhakar Laxman JatharEndocrinologist46yrs exp

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lybrate-user, Thanks for the query. As mentioned your FBG is fine (93 mg), but PP is definitely high. The reason for fasting being low is the Insulin dosage being taken at night. You need to reduce the post lunch glucose level. So you may look at increasing only Glimepiride dosage rather than taking two tablets of double dose of both (glimiperide + Metformin). That may become excess. If you have any specific questions please do come back. You should target PP <100 mg (as is now), PP 150 to 170 mg HbA1c%<6.8.8. Apart from tablets diet restriction and exercise also have to be looked at. Thanks. 

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