About my wife back pain started in her lumber and thoracic back portion in the month of feb. 2012. We started treatment under local doctor's advice and took pain killers and some muscle relaxant and pain healed. But, it got repeated every week and we did the same treatment for the span of month. After that we did total analysis and it was found that there is compression at d8-d-9 and infection from d8-d10 and l3-l4 of spine. Then we did biopsy (first biopsy) of developed lesions and all reports were normal. At this time othopedician doctor advise us that it can be non-detectable tb infection (as it is non-pulmonary) and we started akt-4 on the basis of symptoms even though mtb was negative up to 4th week of culture growth. She took akt-4 for 20 months (june 2012 to feb-2014). During last 6 months of this time of period she was absolutely fine and started normal movements which were restricted during initial part of treatment. Infection was healed partially, and lesions was also started to disappear. We monitored it by ct scan after every 3 months. But in dec 2014 when medicine supposed to stop completely, again sever back pain started and it was found that there is formation of pus and damage of tissues at d8-d10, l3-l4. During this time of period she suddenly lost her weight by 18 kg (within 15 days), so operated and currated all the pus and infected part from the infected location (second biopsy). That sample we again sent for all the lab tests and it is again negative for mtb. We cultured that sample further and it is fount that this is slow growing ntm (non tuberculin mycobacterium) infection. And rest of all test were normal. As it is very slow growing we cannot found out exact genome of that bacterium. So, at this time infectious disease specialist and spine specialist doctors took decision together and stop akt 4 and started her; 1. Amikacin sulphate 1g: daily im/iv 2. Clarrithromycin: 500mg twice a day 3. Doxycyclin and lactic acid bacillus: twice a day 4. Levofloxacin: 750mg once a day during this treatment only her bsl found high without any diabetic history; so she is also taking, 5. Reclide 80mg twice a day 6. Metformine 500 mg twice a day as amikacin daily 1 gm is very high dose we are monitoring her serum creatinine, lft, esr, crp level on weekly basis; and if serum creatinine level is above standard value doctor advising to stop amikacin for some time and once it comes to normal level again we are starting it. Rests of the medicines are same. Above mentioned medicine has been taken for 4.5 months and again we did contrast mri for analyzing effectiveness of therapy. But in this latest mri report it is found that there is new disease has been developed at d9-d10 vertebral bodies and intervention disc. So, we taken advice from Dr. Rajeev soman, hinduja, mumbai. He has diagnosed it as below; 1. Primary tuberculine infection 2. Secondary nosocomial infection 3. Non-tubeculine mycobacterium and prescribed following medicines for 6 months; 1. Inj. Tigecycline (tiganex) 50 mg, bd - 6 months 2. Tab. Clarrithromycine (synclar) 500 mg, bd - 6 months 3. Tab. Levofloxacine (levoflox) 750 mg, od - 6 months 4. Tab. Linezolid 600 mg, od - 6 months } now all medicines stopped due to severe side effect. Side effect recovery is going on. What should we do?