Hi, My father is suffering from systolic hypertension. He is diagnosed 3 years back. The hypertension history is first he was given with amlodipine+valsartan 5/80 mg (exforge) before sleep when he take that medicine his systolic blood pressure become normal but diastolic decreases to 50 or less then the medication was changed and he started with amlodipine 5 mg (Norvasc) before sleep but the problem remains same then the physician changed it from 5 mg to Amlodipine 2.5 mg (Lodopin) before sleep but the problem remain same and there was no success. We were referred to cardiologist who after taking the echo and ecg said that he is having no cardiac issues and suggested losartan 50 mg (eziday) before sleep. Now with this medication the issue is that his diastolic comes to normal if he takes medicine but systolic is going high up to 175 - 185 then he changes it to valsartan 80 mg (diovan) before sleep but the problem remain same with this medicine but the slight change that appears is his blood pressure remains normal till mid day and after mid day it starts going up and till night it again reaches to 165-175. I want to ask is there any solution for the above case. Your response will be much appreciated.