I am 32 years old and suffering from depression since last 12 years. I have been administered with mirtaz, amitriptyline, quetiapine, oleanz,and ect was also given to me. Currently I am taking imipramine, trazodone, chlorotame ,quetiapine, paroxetine, venlafaxine, but my condition is not improving .i am also addicted benzodiazepine. I take lorazepam 2 (mg) one in day and one at night.

Dr. Saul PereiraPsychologist48yrs exp

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You are being treated for 12 years and it sound like you have done any counseling in the interim. In counseling you will learn a lot of skills and tools to handle your depression from a behavioral point of view. Medication doesn't teach you any adaptations. So when the medication is withdrawn, you could go into reactions of withdrawal. In the meantime please do the following sincerely because you could resolve the problem better with good cooperation: have a good night?s sleep, have a good breakfast of more proteins, meditate often, remain free of stress, eat a lot of fiber, nuts, avocado, exercise regularly, eat dark chocolate, do yoga meditation exercises, spend time in nature or gardening, etc. I suggest you do the opposite of what this depression makes you feel like doing (actually, not doing): you will need to fight this condition. You must become active; stay upright during the daylight time; meet people; never sleep during the day, wake up by 6 am every day, play some active games, especially contact games, do physical exercises, talk to people and join some social clubs, attend yoga classes etc. Watch sitcoms on tv or comedies and cheer yourself up. Go for excursions in groups, for outings, camps, conferences, and religious conventions. Get a pet dog and spend time training it, exercising it and relating to it. Expose yourself to some sunlight every day, at least, 30 minutes but not in the scorching heat. Whatever happens, please incorporate these three important adaptations in your life: always be responsible, be respectful, and be functional. If you did these three, lots of things will go well in life. Please pray and have faith in god to alleviate your sufferings. Don?t wait for others to help. Use your own motivation, which might be at its lowest, but persevere and win this battle. Above all to be really happy, you need to live in love and for love. Learn all about emotions and how to handle them and that will get you out of the depression rather easily and quickly. A counselor is there only to facilitate you, all the hard word must come from you, and your cooperation with that person is very critical for your success. Be positive every day and learn to be contented with what you have. Do some left brain exercises: it is the happy brain. Here are a few suggestions: shut your left nostril and breathe, move your eyes from right to left and vice versa for at least half a minute at a time, and do calisthenic exercises with some form of counting, regularly. Whatever happens please cooperate with the therapy and do not discontinue until the condition is completely resolved.  

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Dr. Aravinda Jawali.Psychiatrist44yrs exp

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Looks like symptoms are therapy resistant. First need to treat drug induced psychosis and benzodiazepine dependency. Of course depression needs care.  

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Dr. Saranya DevanathanPsychiatrist48yrs exp

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Deer Pankaj, Lorazepam addiction also needs treatment along with your depression. Though you have mentioned the tablets name, you have not mentioned the maximum dose tried and the duration of each tablet taken. If it is maximum dose and adequate duration, you will be given add-ons of intractable depression. There are many more that will be added to your antidepressant. Any therapy if added, most of the psycho social problems of depression can be resolved. Your quality of life will improve in spite of depression. 

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