What is divalproex sodium? Divalproex sodium affects chemicals in the body that may be involved in causing seizures. Divalproex sodium is used to treat various types of seizure disorders. Divalproex sodium is sometimes used together with other seizure medications. Divalproex sodium is also used to treat manic episodes related to bipolar disorder (manic depression), and to prevent migraine headaches. Divalproex sodium generic name: divalproex sodium (dye val pro ex) brand name: depakote er, depakote sprinkles, depakote (obsolete), depakote medically reviewed by drugs.com.