I am a patient of diabetes. Normal readings are bt. 150 to 370 approx. Taking the medicine named istamet 50/500as recommended by my doctor but now after consulting to my doctor I started taking glycomet gp1 tablet each on single day as same as previous one. What is the difference between both the tablets and what these tablets do in my body after intake.

Dr. Prabhakar Laxman JatharEndocrinologist51yrs exp

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Monika ji Thanks for the query. I have seen the details given. The glucose levels mentioned are very high, showing you have uncontrolled diabetes. This needs to be rapidly brought under control. In a well controlled diabetes FBG should be < 100 mg or closer to 100 mg. PP should be 150 to 170 mg & HbA1c% < 6.5% (not mentioned) The tablets given tend to increase insulin secretion by different mechanisms and help reduce blood glucose levels. Istamet contains Sitagliptin it belongs to DPP -IV inhibitor a drug supposed to increase insulin secretion depending upon presence of glucose coming from food. Metformin helps slow down carbohydrate absorption plus reduces resistance to insulin action. Glimiperide is a sulfonylurea, that directly stimulates Beta cells to produce insulin. Thus each drug has different modes of action. But the objective is to help reduce blood glucose to be moved to muscles and other tissue cells for storage or actual action. Looking at your glucose levels you may have to take both those tablets plus take a properly planned diet, so that intake is restricted. There is no mention of your weight, diet, extent of daily exercise that is being done. No information on lipid profile and BP readings. All these details need to be known to give any suggestions or help improve glucose control. Thanks. 

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Dr. Karuna ChawlaHomeopathy Doctor26yrs exp

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Along with medicines follow diabetes diet which simply means eating the healthiest foods in moderate amounts and sticking to regular mealtimes. A diabetes diet is a healthy-eating plan that's naturally rich in nutrients and low in fat and calories. Key elements are fruits, vegetables and whole grains. U can take (moderate amount) grapes. Apples. Berries. Citrus fruits. Papaya. U should avoid sugar-sweetened beverages. Sugary beverages are the worst drink choice for someone with diabetes. Trans fats sugar, cake, pastries mithai/sweets chocolate fruits like mango, litchi etc. White bread, pasta fruit-flavored yogurt. Sweetened breakfast cereals. Flavored coffee drinks. Honey 1. Don't take tea empty stomach. Eat something like a banana (if you are not diabetic) or soaked almonds or any seasonal fruit. No only biscuits or rusk will not do. 2. Take your breakfast every day. Don't skip it. 3. Have light meals every 2 hours (in addition to your breakfast, lunch n dinner) e.g. Nariyal paani, chaach, a handful of dry fruits, a handful of peanuts, seasonal fruit, a cup of curd/milk etc 4. Finish your dinner at least 2 hours before going to sleep. 5. Maintain active life style 6. Avoid fast foods, spicy n fried foods 7.take a lot of green vegetables n fruit. 8. Drink lot of water. 9.curd is good for u. Exercise in the form of yoga, cycling, swimming, gymming, walking etc. Now about point no. 5. You should join a gym for weight training. Do it 2-3 times a week with at least 48 hours in between 2 sessions. For more details you can consult me.  

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Dr. M S SeshadriEndocrinologist49yrs exp

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Dear lybrate-user, lycomet gp1 has metformin and glimiperide, metformin makes insulin work better and glimiperide stimulates secretion of insulin from your pancreas. Watch out for low sugar symptoms after you have made the change reduce the quantity of carbohydrate (rice, wheat, rava, maida) in each meal and increase the quantity of protein (dhal, egg white, fish or chicken). Monitor blood sugars with glucometer as follows. Fasting and pp on wednesday and 2 hour after lunch and after dinner on sunday and maintain a record. Target fasting < 120 pp < 160 mg/dl if in spite of dietary adjustment you sugar levels continue to be high and if your hba1c is more than 8 % seek a consultation to adjust your anti-diabetic drugs. 

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