My mother is 58 year old. She is diabetic and bp patient since last 20 years. Her creatinine level is 3.0 at present. Bp 175/90 after taking following medicine sugar is in control (taking insulin novorapid 18 units three times) medicine as 1.moxinidine 0.3 (morning-evening) 2.cilnidipine 10 mg (morning- afternoon-evening) 3. Betaloc 25 (morning-evening) 4. Dytor 10 (morning-evening) ketosteril and nefrosave fort two times. Now problem is 1.she not release bathroom freely (main problem) 2. Slightly swelling on face 3. Fatigue.