I am suffering from diabetes insipidus for the past 35 years and take chlorpropamide 250 mg tablet per day. Now I am unable to get the same tablet in the market. All other my parameters are normal. Kindly suggest me an alternative medicine as the said one is not available in the market.

Dr. Prabhakar Laxman JatharEndocrinologist51yrs exp

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Hello, thanks for the query. Diabetes insipidus is usually treated with injections of hormone adh or desmopressin (typically, this form is treated with a man-made hormone called desmopressin (ddavp, minirin, others). This medication replaces the missing anti-diuretic hormone (adh) and decreases urination. You can take desmopressin as a nasal spray, as oral tablets or by injection.) I am not aware that chlorpropamide is used for that condition. In that condition a person passes almost 20 liters of urine because of absence of hormone adh. Plus the drug that you have mentioned was used some decades bac for treating diabetes mellitus for glucose control. Now it is discontinued. Thanks.  

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