Hello! I have been suffering from severe major depression and anxiety since 3 years. I changed many doctors and medicines but to no avail. The doctor I am seeing currently diagnosed me with treatment resistant depression and bipolar effective disorder a year ago, even though I do not experience the manic highs or even hypomania. He put me through ect 22 times which only marginally improved my situation, before ect I used to cry and yell all day. I have extreme fatigue, low motivation, anger irritation, fear, loss of appetite, weight gain due to medications, tremors, loss of confidence, crying spells, blurred vision and extreme weakness due to depression. I am terrified of going outside and blurred vision adds to the fear. Doctors have tried almost all medications: venlafaxine, escitalopram, olanzapine, quetiapine, lithium, valproic acid, paroxetine, clomipramine, and anxiety meds like xanax, rivotril, amylene etc. Right now doctor has put me on clonazepam and prothiaden since 3 weeks, but I have seen no improvement. I took lithium and valproic acid for about 8 months and they only added to my fatigue and weight gain so doctor stopped them. I really need help in terms of medication as I am still hoping there might be one which could take me out of this extreme pain. I am terrified that if I do not get the right help or if there is not a cure, I will have to live like this for my entire life, in bed and barely able to think, eat, move or understand anything. I am 36 years of age, female and from pakistan. I have heard that indian doctors are good. Please help me out of this and suggest any medication and save my life. Thanking you!