I have a very bad mood with anxiety and fatigue since 10 years. My doctor prescribed separately zoloft 100 mg, venlafaxine 300 mg, paroxetine 20 mg, fluoxetine 40 mg, escitalopram 20 mg, brintelix 20 mg, valdoxan. Always with some axillary such as depakine 500 mg, amisulpride 50 mg, sifrol 0.18 mg, tofranil 25 mg, anafranil 10 mg. I also tried modafinil 200 mg. There was not any improvement. Blood test is perfect. Vitamin d is ok. Could you give me some advices or a some drugs to try? Thanks a lot.

Ms. M Sri Vidhya VenkatesanPsychologist22yrs exp

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Hi lybrate-user! you can try counseling and psychotherapy to overcome the same.  

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Dr. Saranya DevanathanPsychiatrist51yrs exp

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Dear Kida, Most of these drugs work at certain dose and also after few weeks of regular intake. i am not sure that you tried them at adequate dose for sufficient time. If you have done it, there are few add ons and supplements for treatment resistant depression. Some time you need to undergo review of the diagnosis. Mostly you need to work on the psychosocial factors maintaining depression and anxiety. 

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Dr. Satya MandalPsychologist9yrs exp

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Taking long list of traditional medicines for anxiety and fatigue at this age is not recommended. You have already tried much of it. If you really reverse back then kindly look after for natural remedies. Consult a good psychologist or psychotherapist immediately. If you want more help then you may message me.  

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