Case of rheumatoid arthritis since 2010. ANA (antinuclear antibody) result: POSITIVE. Doctors diagnosed as Sjogren's syndrome. Taking Zempred-4 mg and HCQS-300 mg daily one. Is there any side effects with above? Is there any fear/danger with sjogren syndrome? I am so thankful if you explain in detail?

Dr. Meha SharmaRheumatologist5yrs exp

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Hello Lybrate User. Sjogren's syndrome is characterised by abnormal functioning of exocrine glands leading to dryness of eyes and mouth. It can be primary sjogren's or secondary (secondary to other connective tissue disorder like RA, SLE, Systemic sclerosis). Just a positive ANA does not confirm sjogren's. ANA can be positive in 30% patients of RA itself. Type of ANA pattern would be relevant. Primary sjogren's have antibodies to Ro and La in 30-50% cases. Sjogren's diagnosis would require other objective signs like positive shirmer's test (dry eyes), ocular staining, positive minor salivary gland biopsy. Now your query about side effects of prescribed medicines. Steroids (zempred) in long term can cause bone weakness (osteoporosis ), diabetes, hypertension, peptic ulcer disease, cataract etc. But it needs to be given if indicated with bone and GI protection. Surely take calcium and vitamin D supplements. Hydroxychloroquine can cause retinal and corneal deposits in eye. You should always get a baseline fundus (eye) examination done when starting this drug, and if normal then every 5 years. Sjogren's can have multiple extraglandular symptoms including fatigue, raynauds, neuropathy, lung inbolvement, arthritis, heart involvement. You should follow up with your rheumatologist regularly. 

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