My husband is 28 years old. High cholesterol values detected recently. Tc-242, ldl-181, hdl-42, tg-94. His father and paternal grandfather died of myocardial infarction. Father died at a younger age of around 42 yrs. I doubt is it due to his genetic predisposition that is leading to this very high levels like apob100 or ldl receptor mutation. If so kindly advice regarding management of his condition. What drugs to start with, ideal dose to start with? I'm his wife and I'm a medicine graduate by profession. Kindly help and give your valuable advice. Thanking you.

Dr. Mohammed SalmanGeneral Physician1yrs exp

90% (49 ratings)

Ask Free Question

Hello doctor. From the above history and investigations, it does not imply there is a genetic defect, if there is family history, it can also mean there is a problem with the diet and lifestyle. As you already know the problems, you can advise him better and make sure he has a healthy lifestyle. Generally in case of inherited disorders the cholestrol levels are very high. I have seen patients with 800+ cholestrol. So the basic protocol applies here too. First diet and lifestyle modifications, then you can start with statin treatment if required. Generally atorvastatin is started as 10 or 20 mg hs, based on the cholestrol levels. Lipid profile is monitored over time and the dose adjusted accordingly. Do not hesitate to ask if you have more queries. 

1 person found this helpful